6C1Q

Crystal structure of human C5a receptor in complex with an orthosteric antagonist PMX53 and an allosteric antagonist NDT9513727

Summary for 6C1Q

• Entry DOI: 10.2210/pdb6c1q/pdb
• Related PRD ID: PRD_002303
• Descriptor: Soluble cytochrome b562, C5a anaphylatoxin chemotactic receptor 1 chimera, PMX53, 1-(1,3-benzodioxol-5-yl)-~{N}-(1,3-benzodioxol-5-ylmethyl)-~{N}-[(3-butyl-2,5-diphenyl-imidazol-4-yl)methyl]methanamine (3 entities in total)
• Functional Keywords: gpcr, membrane protein
• Biological source: Escherichia coli; More
• Total number of polymer chains: 2
• Total formula weight: 48978.27

Authors

Liu, H.,Wang, L.,Wei, Z.,Zhang, C. (deposition date: 2018-01-05, release date: 2018-05-30, Last modification date: 2020-01-08)

• Primary citation: Liu, H.,Kim, H.R.,Deepak, R.N.V.K.,Wang, L.,Chung, K.Y.,Fan, H.,Wei, Z.,Zhang, C.; Orthosteric and allosteric action of the C5a receptor antagonists.; Nat. Struct. Mol. Biol., 25:472-481, 2018; PubMed: 29867214; DOI: 10.1038/s41594-018-0067-z

Experimental method

X-RAY DIFFRACTION (2.9 Å)