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6C1Q

Crystal structure of human C5a receptor in complex with an orthosteric antagonist PMX53 and an allosteric antagonist NDT9513727

Functional Information from GO Data
ChainGOidnamespacecontents
B0004875molecular_functioncomplement receptor activity
B0004930molecular_functionG protein-coupled receptor activity
B0005506molecular_functioniron ion binding
B0006935biological_processchemotaxis
B0007186biological_processG protein-coupled receptor signaling pathway
B0009055molecular_functionelectron transfer activity
B0016020cellular_componentmembrane
B0020037molecular_functionheme binding
B0022900biological_processelectron transport chain
B0042597cellular_componentperiplasmic space
B0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues10
Detailsbinding site for residue 9P2 B 501
ChainResidue
BILE210
BTHR303
BLEU211
BALA214
BTHR215
BALA242
BVAL245
BLEU295
BTRP299
BPRO300

site_idAC2
Number of Residues15
Detailsbinding site for PMX53 chain L
ChainResidue
BLEU178
BSER181
BPRO199
BARG261
BVAL262
BARG264
BCYS274
BGLY275
BVAL276
BSER279
BTYR344
BTHR347
BGLY348
BASP368
BVAL372

Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIlLLATISADRFLlV
ChainResidueDetails
BALA208-VAL224

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING: axial binding residue
ChainResidueDetails
BTRP16
BILE111

site_idSWS_FT_FI2
Number of Residues26
DetailsTRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:29300009
ChainResidueDetails
BILE124-PHE150

site_idSWS_FT_FI3
Number of Residues39
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:29300009
ChainResidueDetails
BGLU151-THR155
BASP219-ALA239
BLEU313-LYS328

site_idSWS_FT_FI4
Number of Residues23
DetailsTRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:29300009
ChainResidueDetails
BILE156-PHE179

site_idSWS_FT_FI5
Number of Residues57
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:29300009
ChainResidueDetails
BTHR180-SER196
BARG261-ARG286
BSER352-ASP368

site_idSWS_FT_FI6
Number of Residues21
DetailsTRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:29300009
ChainResidueDetails
BILE197-ALA218

site_idSWS_FT_FI7
Number of Residues20
DetailsTRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:29300009
ChainResidueDetails
BTRP240-TYR260

site_idSWS_FT_FI8
Number of Residues25
DetailsTRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:29300009
ChainResidueDetails
BALA287-LEU312

site_idSWS_FT_FI9
Number of Residues22
DetailsTRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:29300009
ChainResidueDetails
BVAL329-MET351

site_idSWS_FT_FI10
Number of Residues20
DetailsTRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:29300009
ChainResidueDetails
BSER369-ALA389

site_idSWS_FT_FI11
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000305|PubMed:7642584
ChainResidueDetails
BSER400

site_idSWS_FT_FI12
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:10636859, ECO:0000269|PubMed:7642584
ChainResidueDetails
BSER403
BSER413

227111

PDB entries from 2024-11-06

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