6C1I
Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with T0070907
Summary for 6C1I
Entry DOI | 10.2210/pdb6c1i/pdb |
Descriptor | Peroxisome proliferator-activated receptor gamma, 2-chloro-5-nitro-N-(pyridin-4-yl)benzamide, nonanoic acid, ... (4 entities in total) |
Functional Keywords | nuclear receptors, tzds, drug design, therapeutic targets, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 63558.61 |
Authors | Shang, J.,Fuhrmann, J.,Brust, R.,Kojetin, D.J. (deposition date: 2018-01-04, release date: 2018-12-12, Last modification date: 2023-10-04) |
Primary citation | Brust, R.,Shang, J.,Fuhrmann, J.,Mosure, S.A.,Bass, J.,Cano, A.,Heidari, Z.,Chrisman, I.M.,Nemetchek, M.D.,Blayo, A.L.,Griffin, P.R.,Kamenecka, T.M.,Hughes, T.S.,Kojetin, D.J. A structural mechanism for directing corepressor-selective inverse agonism of PPAR gamma. Nat Commun, 9:4687-4687, 2018 Cited by PubMed: 30409975DOI: 10.1038/s41467-018-07133-w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.26 Å) |
Structure validation
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