6C1I

Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with T0070907

Summary for 6C1I

• Entry DOI: 10.2210/pdb6c1i/pdb
• Descriptor: Peroxisome proliferator-activated receptor gamma, 2-chloro-5-nitro-N-(pyridin-4-yl)benzamide, nonanoic acid, ... (4 entities in total)
• Functional Keywords: nuclear receptors, tzds, drug design, therapeutic targets, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 63558.61

Authors

Shang, J.,Fuhrmann, J.,Brust, R.,Kojetin, D.J. (deposition date: 2018-01-04, release date: 2018-12-12, Last modification date: 2023-10-04)

• Primary citation: Brust, R.,Shang, J.,Fuhrmann, J.,Mosure, S.A.,Bass, J.,Cano, A.,Heidari, Z.,Chrisman, I.M.,Nemetchek, M.D.,Blayo, A.L.,Griffin, P.R.,Kamenecka, T.M.,Hughes, T.S.,Kojetin, D.J.; A structural mechanism for directing corepressor-selective inverse agonism of PPAR gamma.; Nat Commun, 9:4687-4687, 2018; PubMed: 30409975; DOI: 10.1038/s41467-018-07133-w

Experimental method

X-RAY DIFFRACTION (2.26 Å)