6C0P
Crystal structure of HIV-1 E138K mutant reverse transcriptase in complex with non-nucleoside inhibitor 25a
Summary for 6C0P
Entry DOI | 10.2210/pdb6c0p/pdb |
Related | 6C0J 6C0K 6C0L 6C0N 6C0O |
Descriptor | Reverse transcriptase/ribonuclease H, Reverse transcriptase p51 subunit, 4-({4-[(4-{4-[(E)-2-cyanoethenyl]-2,6-dimethylphenoxy}thieno[3,2-d]pyrimidin-2-yl)amino]piperidin-1-yl}methyl)benzene-1-sulfonamide, ... (8 entities in total) |
Functional Keywords | non-nucleoside inhibitor, replication |
Biological source | Human immunodeficiency virus type 1 group M subtype B (isolate BH10) More |
Total number of polymer chains | 2 |
Total formula weight | 117246.35 |
Authors | Yang, Y.,Nguyen, L.A.,Smithline, Z.B.,Steitz, T.A. (deposition date: 2018-01-01, release date: 2018-08-01, Last modification date: 2023-10-04) |
Primary citation | Yang, Y.,Kang, D.,Nguyen, L.A.,Smithline, Z.B.,Pannecouque, C.,Zhan, P.,Liu, X.,Steitz, T.A. Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors. Elife, 7:-, 2018 Cited by PubMed: 30044217DOI: 10.7554/eLife.36340 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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