6BZ9

Crystal structure of human caspase-1 in complex with Ac-FLTD-CMK

Summary for 6BZ9

• Entry DOI: 10.2210/pdb6bz9/pdb
• Descriptor: Caspase-1, Ac-FLTD-CMK, DI(HYDROXYETHYL)ETHER, ... (5 entities in total)
• Functional Keywords: inhibitor, complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 30893.88

Authors

Xiao, T.S.,Yang, J.,Liu, Z.,Wang, C.,Yang, R. (deposition date: 2017-12-22, release date: 2018-06-13, Last modification date: 2023-10-04)

• Primary citation: Yang, J.,Liu, Z.,Wang, C.,Yang, R.,Rathkey, J.K.,Pinkard, O.W.,Shi, W.,Chen, Y.,Dubyak, G.R.,Abbott, D.W.,Xiao, T.S.; Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor.; Proc. Natl. Acad. Sci. U.S.A., 115:6792-6797, 2018; PubMed: 29891674; DOI: 10.1073/pnas.1800562115

Experimental method

X-RAY DIFFRACTION (1.796 Å)