6BZ9

Crystal structure of human caspase-1 in complex with Ac-FLTD-CMK

6BZ9 の概要

• エントリーDOI: 10.2210/pdb6bz9/pdb
• 分子名称: Caspase-1, Ac-FLTD-CMK, DI(HYDROXYETHYL)ETHER, ... (5 entities in total)
• 機能のキーワード: inhibitor, complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 30893.88

構造登録者

Xiao, T.S.,Yang, J.,Liu, Z.,Wang, C.,Yang, R. (登録日: 2017-12-22, 公開日: 2018-06-13, 最終更新日: 2023-10-04)

• 主引用文献: Yang, J.,Liu, Z.,Wang, C.,Yang, R.,Rathkey, J.K.,Pinkard, O.W.,Shi, W.,Chen, Y.,Dubyak, G.R.,Abbott, D.W.,Xiao, T.S.; Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor.; Proc. Natl. Acad. Sci. U.S.A., 115:6792-6797, 2018; PubMed: 29891674; DOI: 10.1073/pnas.1800562115

実験手法

X-RAY DIFFRACTION (1.796 Å)