6BZ4

Human IgG1 lacking complement-dependent cytotoxicity: hu3S193 Fc mutant K322A

Summary for 6BZ4

• Entry DOI: 10.2210/pdb6bz4/pdb
• Related: 4WI2 4WI3 4WI4 4WI5 4WI6 4WI7 4WI8 4WI9
• Descriptor: Immunoglobulin gamma-1 heavy chain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: immunoglobulin g, fc engineering, complement dependent cytotoxicity, immune system
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 49589.39

Authors

Farrugia, W.,Burvenich, I.G.J.,Scott, A.M.,Ramsland, P.A. (deposition date: 2017-12-22, release date: 2018-06-13, Last modification date: 2023-10-04)

• Primary citation: Burvenich, I.J.G.,Farrugia, W.,Liu, Z.,Makris, D.,King, D.,Gloria, B.,Perani, A.,Allan, L.C.,Scott, A.M.,Ramsland, P.A.; Global conformational changes in IgG-Fc upon mutation of the FcRn-binding site are not associated with altered antibody-dependent effector functions.; Biochem. J., 475:2179-2190, 2018; PubMed: 29794155; DOI: 10.1042/BCJ20180139

Experimental method

X-RAY DIFFRACTION (2.4 Å)