6BYO

Residue assignment correction to the voltage gated calcium Cav1.1 rabbit alpha 1 subunit PDB entries 3JBR & 5GJV

6BYO の概要

• エントリーDOI: 10.2210/pdb6byo/pdb
• 関連するPDBエントリー: 3JBR 5GJV
• EMDBエントリー: 9513
• 分子名称: Voltage-dependent L-type calcium channel subunit alpha-1S (1 entity in total)
• 機能のキーワード: voltage-gated calcium channels, membrane protein
• 由来する生物種: Oryctolagus cuniculus (Rabbit)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 155063.56

構造登録者

Cardozo, T.J.,Martinez-Ortiz, W. (登録日: 2017-12-21, 公開日: 2018-05-02, 最終更新日: 2024-10-16)

主引用文献

Martinez-Ortiz, W.,Cardozo, T.J.
An Improved Method for Modeling Voltage-Gated Ion Channels at Atomic Accuracy Applied to Human CavChannels.
Cell Rep, 23:1399-1408, 2018

PubMed Abstract: Voltage-gated ion channels (VGICs) are associated with hundreds of human diseases. To date, 3D structural models of human VGICs have not been reported. We developed a 3D structural integrity metric to rank the accuracy of all VGIC structures deposited in the PDB. The metric revealed inaccuracies in structural models built from recent single-particle, non-crystalline cryo-electron microscopy maps and enabled the building of highly accurate homology models of human Ca channel α subunits at atomic resolution. Human Ca Mendelian mutations mostly located to segments involved in the mechanism of voltage sensing and gating within the 3D structure, with multiple mutations targeting equivalent 3D structural locations despite eliciting distinct clinical phenotypes. The models also revealed that the architecture of the ion selectivity filter is highly conserved from bacteria to humans and between sodium and calcium VGICs.

PubMed: 29719253
DOI: 10.1016/j.celrep.2018.04.024

実験手法

ELECTRON MICROSCOPY (3.6 Å)