6BY8
Menin in complex with MI-1482
Summary for 6BY8
Entry DOI | 10.2210/pdb6by8/pdb |
Descriptor | Menin, 4-methyl-1-{[(2R)-5-oxomorpholin-2-yl]methyl}-5-[(4-{[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino}piperidin-1-yl)methyl]-1H-indole-2-carbonitrile, DIMETHYL SULFOXIDE, ... (7 entities in total) |
Functional Keywords | protein binding, inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 1 |
Total formula weight | 56153.08 |
Authors | Borkin, T.,Klossowski, S.,Pollock, J.,Linhares, B.,Cierpicki, T.,Grembecka, J. (deposition date: 2017-12-20, release date: 2018-11-28, Last modification date: 2023-10-04) |
Primary citation | Borkin, D.,Klossowski, S.,Pollock, J.,Miao, H.,Linhares, B.M.,Kempinska, K.,Jin, Z.,Purohit, T.,Wen, B.,He, M.,Sun, D.,Cierpicki, T.,Grembecka, J. Complexity of Blocking Bivalent Protein-Protein Interactions: Development of a Highly Potent Inhibitor of the Menin-Mixed-Lineage Leukemia Interaction. J.Med.Chem., 61:4832-4850, 2018 Cited by PubMed: 29738674DOI: 10.1021/acs.jmedchem.8b00071 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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