6BY8

Menin in complex with MI-1482

6BY8 の概要

• エントリーDOI: 10.2210/pdb6by8/pdb
• 分子名称: Menin, 4-methyl-1-{[(2R)-5-oxomorpholin-2-yl]methyl}-5-[(4-{[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino}piperidin-1-yl)methyl]-1H-indole-2-carbonitrile, DIMETHYL SULFOXIDE, ... (7 entities in total)
• 機能のキーワード: protein binding, inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 56153.08

構造登録者

Borkin, T.,Klossowski, S.,Pollock, J.,Linhares, B.,Cierpicki, T.,Grembecka, J. (登録日: 2017-12-20, 公開日: 2018-11-28, 最終更新日: 2023-10-04)

• 主引用文献: Borkin, D.,Klossowski, S.,Pollock, J.,Miao, H.,Linhares, B.M.,Kempinska, K.,Jin, Z.,Purohit, T.,Wen, B.,He, M.,Sun, D.,Cierpicki, T.,Grembecka, J.; Complexity of Blocking Bivalent Protein-Protein Interactions: Development of a Highly Potent Inhibitor of the Menin-Mixed-Lineage Leukemia Interaction.; J.Med.Chem., 61:4832-4850, 2018; PubMed: 29738674; DOI: 10.1021/acs.jmedchem.8b00071

実験手法

X-RAY DIFFRACTION (1.9 Å)