6BWK
Crystal structure of the human MLKL pseudokinase domain T357E/S358E mutant
Summary for 6BWK
Entry DOI | 10.2210/pdb6bwk/pdb |
Descriptor | Mixed lineage kinase domain-like protein, GLYCEROL (3 entities in total) |
Functional Keywords | pseudokinase, necroptosis, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 33175.17 |
Authors | Cowan, A.D.,Czabotar, P.E.,Murphy, J.M. (deposition date: 2017-12-15, release date: 2018-06-27, Last modification date: 2023-10-04) |
Primary citation | Petrie, E.J.,Sandow, J.J.,Jacobsen, A.V.,Smith, B.J.,Griffin, M.D.W.,Lucet, I.S.,Dai, W.,Young, S.N.,Tanzer, M.C.,Wardak, A.,Liang, L.Y.,Cowan, A.D.,Hildebrand, J.M.,Kersten, W.J.A.,Lessene, G.,Silke, J.,Czabotar, P.E.,Webb, A.I.,Murphy, J.M. Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis. Nat Commun, 9:2422-2422, 2018 Cited by PubMed: 29930286DOI: 10.1038/s41467-018-04714-7 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.79 Å) |
Structure validation
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