6BVJ

Ras:SOS:Ras in complex with a small molecule activator

Summary for 6BVJ

DescriptorGTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (10 entities in total)
Functional Keywordsras, sos, inhibitor, oncoprotein, protein-protein complex, mapk, signaling protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains3
Total molecular weight95984.51
Authors
Phan, J.,Abbott, J.,Fesik, S.W. (deposition date: 2017-12-13, release date: 2018-10-24)
Primary citation
Abbott, J.R.,Hodges, T.R.,Daniels, R.N.,Patel, P.A.,Kennedy, J.P.,Howes, J.E.,Akan, D.T.,Burns, M.C.,Sai, J.,Sobolik, T.,Beesetty, Y.,Lee, T.,Rossanese, O.W.,Phan, J.,Waterson, A.G.,Fesik, S.W.
Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling.
J. Med. Chem., 2018
PubMed: 29856609 (PDB entries with the same primary citation)
DOI: 10.1021/acs.jmedchem.8b00360
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.747 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.1684 0.1% 1.1% 2.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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