6BVI の概要
| 分子名称 | GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (10 entities in total) |
|---|---|
| 機能のキーワード | ras, sos, inhibitor, oncoprotein, protein-protein complex, mapk, signaling protein |
| 由来する生物種 | Homo sapiens (Human) |
| ポリマー鎖数 | 3 |
| 分子量合計 | 95892.42 |
| 構造登録者 | |
| 主引用文献 | Abbott, J.R.,Hodges, T.R.,Daniels, R.N.,Patel, P.A.,Kennedy, J.P.,Howes, J.E.,Akan, D.T.,Burns, M.C.,Sai, J.,Sobolik, T.,Beesetty, Y.,Lee, T.,Rossanese, O.W.,Phan, J.,Waterson, A.G.,Fesik, S.W. Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling. J. Med. Chem., 61:6002-6017, 2018 PubMed: 29856609 (主引用文献が同じPDBエントリー) DOI: 10.1021/acs.jmedchem.8b00360  Import into Mendeley |
| 実験手法 | X-RAY DIFFRACTION (1.746 Å) |
