6BUS
Extended E2 DNA-binding domain of the Bovine Papillomavirus-1
Summary for 6BUS
| Entry DOI | 10.2210/pdb6bus/pdb |
| Descriptor | Regulatory protein E2 (2 entities in total) |
| Functional Keywords | open reading frame, e2, bpv-1, dna binding protein |
| Biological source | Bovine papillomavirus type 1 |
| Total number of polymer chains | 4 |
| Total formula weight | 46308.65 |
| Authors | Leroy, L.M.D.,Barbosa, J.A.R.G.,Polikarpov, I.,Pinheiro, C.B. (deposition date: 2017-12-11, release date: 2018-01-10, Last modification date: 2023-10-04) |
| Primary citation | Leroy, L.,Barbosa, J.A.R.G.,de Prat-Gay, G.,Polikarpov, I.,Pinheiro, C.B. The structure of the extended E2 DNA-binding domain of the bovine papillomavirus-1. Proteins, 88:106-112, 2020 Cited by PubMed Abstract: Bovine papillomavirus proteins were extensively studied as a prototype for the human papillomavirus. Here, the crystal structure of the extended E2 DNA-binding domain of the dominant transcription regulator from the bovine papillomavirus strain 1 is described in the space group P3 21. We found two protein functional dimers packed in the asymmetric unit. This new protein arrangement inside the crystal led to the reduction of the mobility of a previously unobserved loop directly involved in the protein-DNA interaction, which was then modeled for the first time. PubMed: 31299114DOI: 10.1002/prot.25773 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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