6BUL
Crystal structure of Staphylococcus aureus ketol-acid reductoisomerase with hydroxyoxamate inhibitor 2
Summary for 6BUL
Entry DOI | 10.2210/pdb6bul/pdb |
Descriptor | Ketol-acid reductoisomerase (NADP(+)), MAGNESIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (6 entities in total) |
Functional Keywords | ketol-acid reductoisomerase, inhibitor, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
Biological source | Staphylococcus aureus (strain bovine RF122 / ET3-1) |
Total number of polymer chains | 2 |
Total formula weight | 78162.12 |
Authors | Kandale, A.,Patel, K.M.,Zheng, S.,You, L.,Guddat, L.W.,Schenk, G.,Schembri, M.A.,McFeary, R.P. (deposition date: 2017-12-10, release date: 2018-12-12, Last modification date: 2023-10-04) |
Primary citation | Kandale, A.,Patel, K.M.,Zheng, S.,You, L.,Guddat, L.W.,Schenk, G.,Schembri, M.A.,McFeary, R.P. Design, synthesis, in vitro activity and crystallisation of novel N-isopropyl-N-hydroxyoxamate derivatives as ketol-acid reductoisomerase (KARI) inhibitors To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.88 Å) |
Structure validation
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