6BUL

Crystal structure of Staphylococcus aureus ketol-acid reductoisomerase with hydroxyoxamate inhibitor 2

6BUL の概要

• エントリーDOI: 10.2210/pdb6bul/pdb
• 分子名称: Ketol-acid reductoisomerase (NADP(+)), MAGNESIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (6 entities in total)
• 機能のキーワード: ketol-acid reductoisomerase, inhibitor, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• 由来する生物種: Staphylococcus aureus (strain bovine RF122 / ET3-1)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 78162.12

構造登録者

Kandale, A.,Patel, K.M.,Zheng, S.,You, L.,Guddat, L.W.,Schenk, G.,Schembri, M.A.,McFeary, R.P. (登録日: 2017-12-10, 公開日: 2018-12-12, 最終更新日: 2023-10-04)

• 主引用文献: Kandale, A.,Patel, K.M.,Zheng, S.,You, L.,Guddat, L.W.,Schenk, G.,Schembri, M.A.,McFeary, R.P.; Design, synthesis, in vitro activity and crystallisation of novel N-isopropyl-N-hydroxyoxamate derivatives as ketol-acid reductoisomerase (KARI) inhibitors; To Be Published,

実験手法

X-RAY DIFFRACTION (1.88 Å)