6BSI

Structure of HIV-1 RT complexed with an RNA/DNA hybrid containing the polypurine-tract sequence

Summary for 6BSI

• Entry DOI: 10.2210/pdb6bsi/pdb
• Descriptor: REVERSE TRANSCRIPTASE P66 SUBUNIT, REVERSE TRANSCRIPTASE P51 SUBUNIT, DNA (5'-D(*GP*TP*TP*TP*TP*TP*CP*TP*TP*TP*TP*GP*TP*TP*AP*TP*TP*GP*TP*GP*GP*CP*C)-3'), ... (8 entities in total)
• Functional Keywords: hiv-rt, dna-rna complex, rnase h, viral protein, viral protein-dna-rna complex, viral protein-dna-rna-inhibitor complex, viral protein/dna/rna/inhibitor
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 4
• Total formula weight: 131111.91

Authors

Tian, L.,Kim, M.,Yang, W. (deposition date: 2017-12-03, release date: 2018-01-03, Last modification date: 2024-05-22)

• Primary citation: Tian, L.,Kim, M.S.,Li, H.,Wang, J.,Yang, W.; Structure of HIV-1 reverse transcriptase cleaving RNA in an RNA/DNA hybrid.; Proc. Natl. Acad. Sci. U.S.A., 115:507-512, 2018; PubMed: 29295939; DOI: 10.1073/pnas.1719746115

Experimental method

X-RAY DIFFRACTION (3.25 Å)