6BSI

Structure of HIV-1 RT complexed with an RNA/DNA hybrid containing the polypurine-tract sequence

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	REVERSE TRANSCRIPTASE P66 SUBUNIT	polymer	558	64126.4	1	UniProt (Q74085) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) UniProt (by SIFTS) (P04585) In PDB	Human immunodeficiency virus 1
2	B	REVERSE TRANSCRIPTASE P51 SUBUNIT	polymer	441	51384.0	1	UniProt (A0A076Q3N8) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) UniProt (by SIFTS) (P04585) In PDB	Human immunodeficiency virus 1
3	D	DNA (5'-D(*GP*TP*TP*TP*TP*TP*CP*TP*TP*TP*TP*GP*TP*TP*AP*TP*TP*GP*TP*GP*GP*CP*C)-3')	polymer	23	7040.5	1		Homo sapiens
4	R	RNA (25-MER)	polymer	25	7980.9	1		Homo sapiens
5	A	(-)-6-CHLORO-4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONE	non-polymer		315.7	1	Chemie (EFZ)
6	A, D	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
7	D, R	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
8		water	water		18.0	5	Chemie (HOH)

Sequence modifications

A: 1 - 557 (UniProt: Q74085)

PDB	External Database	Details
Gly 0	-	expression tag
Gly 68	Ser 235	conflict
Lys 83	Arg 250	conflict
Met 357	Thr 524	conflict
Val 411	Ile 578	conflict
Lys 461	Arg 628	conflict
His 483	Tyr 650	conflict
Gln 512	Lys 679	conflict

B: 1 - 440 (UniProt: A0A076Q3N8)

PDB	External Database	Details
Gly 0	-	expression tag
Gly 68	Ser 235	conflict
Lys 83	Arg 250	conflict
Val 411	Ile 578	conflict

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	130531.9
Non-Polymers*	Number of molecules	5
	Total formula weight	580.0
All*	Total formula weight	131111.9

*Water molecules are not included.