6BRU

Crystal Structure of the Human vaccinia-related kinase bound to a (S)-2-phenylaminopteridinone inhibitor

6BRU の概要

• エントリーDOI: 10.2210/pdb6bru/pdb
• 分子名称: Serine/threonine-protein kinase VRK1, SULFATE ION, (7S)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7,8-trimethyl-7,8-dihydropteridin-6(5H)-one, ... (5 entities in total)
• 機能のキーワード: transferase, protein kinase domain, structural genomics, structural genomics consortium, sgc, transferase-transferase inhibitor complex, transferase-transferase inhbitor complex, transferase/transferase inhbitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 166149.75

構造登録者

Counago, R.M.,dos Reis, C.V.,de Souza, G.P.,Aquino, B.,Azevedo, A.,Guimaraes, C.,Mascarello, A.,Gama, F.,Ferreira, M.,Massirer, K.B.,Arruda, P.,Edwards, A.M.,Elkins, J.M.,Structural Genomics Consortium (SGC) (登録日: 2017-12-01, 公開日: 2017-12-13, 最終更新日: 2023-10-04)

• 主引用文献: Counago, R.M.,dos Reis, C.V.,de Souza, G.P.,Aquino, B.,Azevedo, H.,Guimaraes, C.,Mascarello, A.,Gama, F.,Ferreira, M.,Massirer, K.B.,Arruda, P.,Edwards, A.M.,Elkins, J.M.,Structural Genomics Consortium (SGC); Crystal Structure of the Human vaccinia-related kinase bound to a (S)-2-phenylaminopteridinone inhibitor; To Be Published,

実験手法

X-RAY DIFFRACTION (1.8 Å)