6BRJ

DDR1 bound to VX-680

6BRJ の概要

• エントリーDOI: 10.2210/pdb6brj/pdb
• 分子名称: Epithelial discoidin domain-containing receptor 1, CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE (3 entities in total)
• 機能のキーワード: kinase, inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 39717.43

構造登録者

Georghiou, G.,Seeliger, M.A. (登録日: 2017-11-30, 公開日: 2018-12-05, 最終更新日: 2023-10-25)

• 主引用文献: Hanson, S.M.,Georghiou, G.,Thakur, M.K.,Miller, W.T.,Rest, J.S.,Chodera, J.D.,Seeliger, M.A.; What Makes a Kinase Promiscuous for Inhibitors?; Cell Chem Biol, 26:390-399.e5, 2019; PubMed: 30612951; DOI: 10.1016/j.chembiol.2018.11.005

実験手法

X-RAY DIFFRACTION (2.231 Å)