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6BRF

Tubulin-RB3_SLD-TTL in complex with heterocyclic pyrimidine compound 4b

Summary for 6BRF
Entry DOI10.2210/pdb6brf/pdb
Related6BR1
DescriptorTubulin alpha-1B chain, 2-chloro-4-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)pyrido[3,2-d]pyrimidine, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
Functional Keywordsmicrotubule inhibitor, colchicine cancer, cell cycle, cell cycle-inhibitor complex, cell cycle/inhibitor
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains6
Total formula weight264964.36
Authors
Kumar, G.,Wang, Y.,Li, W.,White, S.W. (deposition date: 2017-11-30, release date: 2018-06-27, Last modification date: 2024-03-13)
Primary citationBanerjee, S.,Arnst, K.E.,Wang, Y.,Kumar, G.,Deng, S.,Yang, L.,Li, G.B.,Yang, J.,White, S.W.,Li, W.,Miller, D.D.
Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy.
J. Med. Chem., 61:1704-1718, 2018
Cited by
PubMed: 29406710
DOI: 10.1021/acs.jmedchem.7b01858
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

217705

數據於2024-03-27公開中

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