6BP4
Structure of the S. pombe Clr4 catalytic domain bound to SAM
Summary for 6BP4
Entry DOI | 10.2210/pdb6bp4/pdb |
Descriptor | Histone-lysine N-methyltransferase, H3 lysine-9 specific, ZINC ION, S-ADENOSYLMETHIONINE, ... (4 entities in total) |
Functional Keywords | methyltransferase, set domain, transferase |
Biological source | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Total number of polymer chains | 2 |
Total formula weight | 69816.69 |
Authors | Currie, M.A.,Moazed, D. (deposition date: 2017-11-21, release date: 2018-07-25, Last modification date: 2023-10-04) |
Primary citation | Iglesias, N.,Currie, M.A.,Jih, G.,Paulo, J.A.,Siuti, N.,Kalocsay, M.,Gygi, S.P.,Moazed, D. Automethylation-induced conformational switch in Clr4 (Suv39h) maintains epigenetic stability. Nature, 560:504-508, 2018 Cited by PubMed: 30051891DOI: 10.1038/s41586-018-0398-2 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7701 Å) |
Structure validation
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