6BP2

Therapeutic human monoclonal antibody MR191 bound to a marburgvirus glycoprotein

Summary for 6BP2

• Entry DOI: 10.2210/pdb6bp2/pdb
• Descriptor: Envelope glycoprotein, Envelope glycoprotein GP2, MR191 Fab Heavy Chain, ... (7 entities in total)
• Functional Keywords: marburg, ravn, glycoprotein, complex, viral protein, viral protein-immune system complex, viral protein/immune system
• Biological source: Marburg marburgvirus; More
• Total number of polymer chains: 4
• Total formula weight: 99612.73

Authors

King, L.B.,Fusco, M.L.,Flyak, A.I.,Ilinykh, P.A.,Huang, K.,Gunn, B.,Kirchdoerfer, R.N.,Hastie, K.M.,Sangha, A.K.,Meiler, J.,Alter, G.,Bukreyev, A.,Crowe, J.E.J.,Saphire, E.O. (deposition date: 2017-11-21, release date: 2018-01-17, Last modification date: 2023-10-04)

• Primary citation: King, L.B.,Fusco, M.L.,Flyak, A.I.,Ilinykh, P.A.,Huang, K.,Gunn, B.,Kirchdoerfer, R.N.,Hastie, K.M.,Sangha, A.K.,Meiler, J.,Alter, G.,Bukreyev, A.,Crowe, J.E.,Saphire, E.O.; The Marburgvirus-Neutralizing Human Monoclonal Antibody MR191 Targets a Conserved Site to Block Virus Receptor Binding.; Cell Host Microbe, 23:101-109.e4, 2018; PubMed: 29324225; DOI: 10.1016/j.chom.2017.12.003

Experimental method

X-RAY DIFFRACTION (3.172 Å)