6BOC

Influenza A M2 transmembrane domain bound to rimantadine in the Inward(open) conformation

6BOC の概要

• エントリーDOI: 10.2210/pdb6boc/pdb
• 分子名称: Matrix protein 2, CHLORIDE ION, (1S)-1-[(3R,5R,7R)-tricyclo[3.3.1.1~3,7~]decan-1-yl]ethan-1-amine, ... (6 entities in total)
• 機能のキーワード: influenza m2, proton channel, membrane protein, rimantadine
• 由来する生物種: Influenza A virus
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 11434.41

構造登録者

Thomaston, J.L.,DeGrado, W.F. (登録日: 2017-11-19, 公開日: 2018-09-19, 最終更新日: 2023-10-04)

• 主引用文献: Thomaston, J.L.,Polizzi, N.F.,Konstantinidi, A.,Wang, J.,Kolocouris, A.,DeGrado, W.F.; Inhibitors of the M2 Proton Channel Engage and Disrupt Transmembrane Networks of Hydrogen-Bonded Waters.; J. Am. Chem. Soc., 140:15219-15226, 2018; PubMed: 30165017; DOI: 10.1021/jacs.8b06741

実験手法

X-RAY DIFFRACTION (2.25 Å)