6BKF
Lysyl-adenylate form of human LigIV catalytic domain with bound DNA substrate in open conformation
Summary for 6BKF
Entry DOI | 10.2210/pdb6bkf/pdb |
Descriptor | DNA ligase 4, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*C)-3'), DNA (5'-D(*GP*TP*CP*CP*GP*AP*CP*GP*AP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... (6 entities in total) |
Functional Keywords | dna double-strand break repair, ligase, nonhomologous end-joining, ligase-dna complex, ligase/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 82033.04 |
Authors | Moon, A.F.,Tumbale, P.P.,Schellenberg, M.J.,Williams, R.S.,Williams, J.G.,Kunkel, T.A.,Pedersen, L.C.,Bebenek, B. (deposition date: 2017-11-08, release date: 2018-07-18, Last modification date: 2023-10-04) |
Primary citation | Kaminski, A.M.,Tumbale, P.P.,Schellenberg, M.J.,Williams, R.S.,Williams, J.G.,Kunkel, T.A.,Pedersen, L.C.,Bebenek, K. Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis. Nat Commun, 9:2642-2642, 2018 Cited by PubMed: 29980672DOI: 10.1038/s41467-018-05024-8 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.25 Å) |
Structure validation
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