6BKC

Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 6a bound to broadly neutralizing antibody AR3B

Summary for 6BKC

• Entry DOI: 10.2210/pdb6bkc/pdb
• Descriptor: Fab AR3B heavy chain, Fab AR3B light chain, Polyprotein, ... (5 entities in total)
• Functional Keywords: hcv, broadly neutralizing antibodies, bnabs, e2 core, ighv1-69, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 69046.24

Authors

Tzarum, N.,Wilson, I.A.,Law, M. (deposition date: 2017-11-08, release date: 2018-12-26, Last modification date: 2023-10-04)

• Primary citation: Tzarum, N.,Giang, E.,Kong, L.,He, L.,Prentoe, J.,Augestad, E.,Hua, Y.,Castillo, S.,Lauer, G.M.,Bukh, J.,Zhu, J.,Wilson, I.A.,Law, M.; Genetic and structural insights into broad neutralization of hepatitis C virus by human VH1-69 antibodies.; Sci Adv, 5:eaav1882-eaav1882, 2019; PubMed: 30613781; DOI: 10.1126/sciadv.aav1882

Experimental method

X-RAY DIFFRACTION (2.6 Å)