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6BF9

Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11-E heavy chain, FAB H11-E light chain

Summary for 6BF9
Entry DOI10.2210/pdb6bf9/pdb
Related6B3Q 6B70 6B7Y 6B7Z 6BF6 6BF7 6BF8
EMDB information7041 7062 7065 7066 7090 7091 7092 7093
DescriptorInsulin-degrading enzyme, Fab H11-E heavy chain, Fab H11-E light chain (3 entities in total)
Functional Keywordside, amyloid beta, hydrolase-immune system complex, hydrolase/immune system
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains6
Total formula weight316023.68
Authors
Liang, W.G.,Zhang, Z.,Bailey, L.J.,Kossiakoff, A.A.,Tan, Y.Z.,Wei, H.,Carragher, B.,Potter, S.C.,Tang, W.J. (deposition date: 2017-10-26, release date: 2018-02-07, Last modification date: 2021-04-28)
Primary citationZhang, Z.,Liang, W.G.,Bailey, L.J.,Tan, Y.Z.,Wei, H.,Wang, A.,Farcasanu, M.,Woods, V.A.,McCord, L.A.,Lee, D.,Shang, W.,Deprez-Poulain, R.,Deprez, B.,Liu, D.R.,Koide, A.,Koide, S.,Kossiakoff, A.A.,Li, S.,Carragher, B.,Potter, C.S.,Tang, W.J.
Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Elife, 7:-, 2018
Cited by
PubMed: 29596046
DOI: 10.7554/eLife.33572
PDB entries with the same primary citation
Experimental method
ELECTRON MICROSCOPY (7.2 Å)
Structure validation

217705

數據於2024-03-27公開中

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