6BEK

Structure of sIHF bound to an 8bp palindromic DNA

6BEK の概要

• エントリーDOI: 10.2210/pdb6bek/pdb
• 分子名称: SCO1480, DNA (5'-D(*CP*AP*TP*GP*CP*AP*TP*G)-3'), POTASSIUM ION, ... (4 entities in total)
• 機能のキーワード: nucleic associated proteins, streptomyces coelicolor, dna binding protein, dna binding protein-dna complex, dna binding protein/dna
• 由来する生物種: Streptomyces coelicolor; 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 32937.35

構造登録者

Guarne, A.,Nanji, T.N.,Shen, Y. (登録日: 2017-10-25, 公開日: 2018-10-31, 最終更新日: 2023-10-04)

主引用文献

Nanji, T.,Gehrke, E.J.,Shen, Y.,Gloyd, M.,Zhang, X.,Firby, C.D.,Huynh, A.,Razi, A.,Ortega, J.,Elliot, M.A.,Guarne, A.
Streptomyces IHF uses multiple interfaces to bind DNA.
Biochim Biophys Acta Gen Subj, 1863:129405-129405, 2019

PubMed Abstract: Nucleoid associated proteins (NAPs) are essential for chromosome condensation in bacterial cells. Despite being a diverse group, NAPs share two common traits: they are small, oligomeric proteins and their oligomeric state is critical for DNA condensation. Streptomyces coelicolor IHF (sIHF) is an actinobacterial-specific nucleoid-associated protein that despite its name, shares neither sequence nor structural homology with the well-characterized Escherichia coli IHF. Like E. coli IHF, sIHF is needed for efficient nucleoid condensation, morphological development and antibiotic production in S. coelicolor.

PubMed: 31376411
DOI: 10.1016/j.bbagen.2019.07.014

実験手法

X-RAY DIFFRACTION (1.7 Å)