6BC7

Cryo X-ray structure of sisomicin bound AAC-VIa

6BC7 の概要

• エントリーDOI: 10.2210/pdb6bc7/pdb
• 分子名称: AAC 3-VI protein, (1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside, ACETATE ION, ... (4 entities in total)
• 機能のキーワード: acetyltransferase, sisomicin, transferase-antibiotic complex, transferase/antibiotic
• 由来する生物種: Enterobacter cloacae
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32851.03

構造登録者

Cuneo, M.J.,Kumar, P. (登録日: 2017-10-20, 公開日: 2018-02-28, 最終更新日: 2023-10-04)

• 主引用文献: Kumar, P.,Serpersu, E.H.,Cuneo, M.J.; A low-barrier hydrogen bond mediates antibiotic resistance in a noncanonical catalytic triad.; Sci Adv, 4:eaas8667-eaas8667, 2018; PubMed: 29632894; DOI: 10.1126/sciadv.aas8667

実験手法

X-RAY DIFFRACTION (1.8 Å)