6BAQ

Mus musculus BPIFA1

6BAQ の概要

• エントリーDOI: 10.2210/pdb6baq/pdb
• 分子名称: BPI fold-containing family A member 1, SODIUM ION, CHLORIDE ION, ... (5 entities in total)
• 機能のキーワード: antimicrobial protein, lung defense protein, surfactant protein, lipid binding protein
• 由来する生物種: Mus musculus (Mouse)
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 203640.84

構造登録者

Little, M.S.,Redinbo, M.R. (登録日: 2017-10-15, 公開日: 2018-05-09, 最終更新日: 2024-10-16)

主引用文献

Little, M.S.,Redinbo, M.R.
Crystal structure of the mouse innate immunity factor bacterial permeability-increasing family member A1.
Acta Crystallogr F Struct Biol Commun, 74:268-276, 2018

PubMed Abstract: Bacterial permeability-increasing family member A1 (BPIFA1) is an innate immunity factor and one of the most abundantly secreted proteins in the upper airways. BPIFA1 is multifunctional, with antimicrobial, surfactant and lipopolysaccharide-binding activities, as well as established roles in lung hydration. Here, the 2.5 Å resolution crystal structure of BPIFA1 from Mus musculus (mBPIFA1) is presented and compared with those of human BPIFA1 (hBPIFA1) and structural homologs. Structural distinctions between mBPIFA1 and hBPIFA1 suggest potential differences in biological function, including the regulation of a key pulmonary ion channel.

PubMed: 29717993
DOI: 10.1107/S2053230X18004600

実験手法

X-RAY DIFFRACTION (2.50260996677 Å)