6BA5

Potent and Selective Antitumor Activity of a T-Cell Engaging Bispecific Antibody Targeting a Membrane-Proximal Epitope of ROR1

Summary for 6BA5

• Entry DOI: 10.2210/pdb6ba5/pdb
• Descriptor: Variable domain of Light Chain, antibody R11, Variable domain Heavy chain, antibody R11, Inactive tyrosine-protein kinase transmembrane receptor ROR1, ... (4 entities in total)
• Functional Keywords: single chain fv, scfv, antibody, ror1, kringle domain, receptor tyrosine kinase-like orphan receptor, phage display, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 12
• Total formula weight: 135665.86

Authors

Park, H.,Rader, C. (deposition date: 2017-10-12, release date: 2018-06-13, Last modification date: 2024-04-03)

• Primary citation: Qi, J.,Li, X.,Peng, H.,Cook, E.M.,Dadashian, E.L.,Wiestner, A.,Park, H.,Rader, C.; Potent and selective antitumor activity of a T cell-engaging bispecific antibody targeting a membrane-proximal epitope of ROR1.; Proc. Natl. Acad. Sci. U.S.A., 115:E5467-E5476, 2018; PubMed: 29844189; DOI: 10.1073/pnas.1719905115

Experimental method

X-RAY DIFFRACTION (1.62 Å)