6BA5
Potent and Selective Antitumor Activity of a T-Cell Engaging Bispecific Antibody Targeting a Membrane-Proximal Epitope of ROR1
Summary for 6BA5
Entry DOI | 10.2210/pdb6ba5/pdb |
Descriptor | Variable domain of Light Chain, antibody R11, Variable domain Heavy chain, antibody R11, Inactive tyrosine-protein kinase transmembrane receptor ROR1, ... (4 entities in total) |
Functional Keywords | single chain fv, scfv, antibody, ror1, kringle domain, receptor tyrosine kinase-like orphan receptor, phage display, immune system |
Biological source | Homo sapiens More |
Total number of polymer chains | 12 |
Total formula weight | 135665.86 |
Authors | |
Primary citation | Qi, J.,Li, X.,Peng, H.,Cook, E.M.,Dadashian, E.L.,Wiestner, A.,Park, H.,Rader, C. Potent and selective antitumor activity of a T cell-engaging bispecific antibody targeting a membrane-proximal epitope of ROR1. Proc. Natl. Acad. Sci. U.S.A., 115:E5467-E5476, 2018 Cited by PubMed: 29844189DOI: 10.1073/pnas.1719905115 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.62 Å) |
Structure validation
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