6BA5

Potent and Selective Antitumor Activity of a T-Cell Engaging Bispecific Antibody Targeting a Membrane-Proximal Epitope of ROR1

6BA5 の概要

• エントリーDOI: 10.2210/pdb6ba5/pdb
• 分子名称: Variable domain of Light Chain, antibody R11, Variable domain Heavy chain, antibody R11, Inactive tyrosine-protein kinase transmembrane receptor ROR1, ... (4 entities in total)
• 機能のキーワード: single chain fv, scfv, antibody, ror1, kringle domain, receptor tyrosine kinase-like orphan receptor, phage display, immune system
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 135665.86

構造登録者

Park, H.,Rader, C. (登録日: 2017-10-12, 公開日: 2018-06-13, 最終更新日: 2024-04-03)

• 主引用文献: Qi, J.,Li, X.,Peng, H.,Cook, E.M.,Dadashian, E.L.,Wiestner, A.,Park, H.,Rader, C.; Potent and selective antitumor activity of a T cell-engaging bispecific antibody targeting a membrane-proximal epitope of ROR1.; Proc. Natl. Acad. Sci. U.S.A., 115:E5467-E5476, 2018; PubMed: 29844189; DOI: 10.1073/pnas.1719905115

実験手法

X-RAY DIFFRACTION (1.62 Å)