6B8J
Co-structure of human glycogen synthase kinase beta with a selective (5-imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine inhibitor
6B8J の概要
エントリーDOI | 10.2210/pdb6b8j/pdb |
分子名称 | Glycogen synthase kinase-3 beta, VAL-SEP-ARG-ARG, GLYCEROL, ... (5 entities in total) |
機能のキーワード | kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Homo sapiens (Human) 詳細 |
細胞内の位置 | Cytoplasm : P49841 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 48037.22 |
構造登録者 | |
主引用文献 | Wagman, A.S.,Boyce, R.S.,Brown, S.P.,Fang, E.,Goff, D.,Jansen, J.M.,Le, V.P.,Levine, B.H.,Ng, S.C.,Ni, Z.J.,Nuss, J.M.,Pfister, K.B.,Ramurthy, S.,Renhowe, P.A.,Ring, D.B.,Shu, W.,Subramanian, S.,Zhou, X.A.,Shafer, C.M.,Harrison, S.D.,Johnson, K.W.,Bussiere, D.E. Synthesis, Binding Mode, and Antihyperglycemic Activity of Potent and Selective (5-Imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine Inhibitors of Glycogen Synthase Kinase 3. J. Med. Chem., 60:8482-8514, 2017 Cited by PubMed: 29016121DOI: 10.1021/acs.jmedchem.7b00922 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.595 Å) |
構造検証レポート
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