6B88
E. coli LepB in complex with GNE0775 ((4S,7S,10S)-10-((S)-4-amino-2-(2-(4-(tert-butyl)phenyl)-4-methylpyrimidine-5-carboxamido)-N-methylbutanamido)-16,26-bis(2-aminoethoxy)-N-(2-iminoethyl)-7-methyl-6,9-dioxo-5,8-diaza-1,2(1,3)-dibenzenacyclodecaphane-4-carboxamide)
Summary for 6B88
Entry DOI | 10.2210/pdb6b88/pdb |
Descriptor | Signal peptidase I, (8S,11S,14S)-14-{[(2S)-4-amino-2-{[2-(4-tert-butylphenyl)-4-methylpyrimidine-5-carbonyl]amino}butanoyl](methyl)amino}-3,18-bis(2-aminoethoxy)-N-[(2Z)-2-iminoethyl]-11-methyl-10,13-dioxo-9,12-diazatricyclo[13.3.1.1~2,6~]icosa-1(19),2(20),3,5,15,17-hexaene-8-carboxamide, PENTAETHYLENE GLYCOL, ... (4 entities in total) |
Functional Keywords | signal peptidase, sbdd, antibiotic, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Escherichia coli (strain K12) |
Total number of polymer chains | 2 |
Total formula weight | 57495.06 |
Authors | Murray, J.M.,Rouge, L. (deposition date: 2017-10-05, release date: 2018-10-10, Last modification date: 2023-10-04) |
Primary citation | Smith, P.A.,Koehler, M.F.T.,Girgis, H.S.,Yan, D.,Chen, Y.,Chen, Y.,Crawford, J.J.,Durk, M.R.,Higuchi, R.I.,Kang, J.,Murray, J.,Paraselli, P.,Park, S.,Phung, W.,Quinn, J.G.,Roberts, T.C.,Rouge, L.,Schwarz, J.B.,Skippington, E.,Wai, J.,Xu, M.,Yu, Z.,Zhang, H.,Tan, M.W.,Heise, C.E. Optimized arylomycins are a new class of Gram-negative antibiotics. Nature, 561:189-194, 2018 Cited by PubMed: 30209367DOI: 10.1038/s41586-018-0483-6 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.407 Å) |
Structure validation
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