6B7H

Structure of mGluR3 with an agonist

6B7H の概要

• エントリーDOI: 10.2210/pdb6b7h/pdb
• 分子名称: Metabotropic glutamate receptor 3, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: mglur3 glutamate, membrane protein-agonist complex, membrane protein/agonist
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 60220.97

構造登録者

Monn, J.A.,Clawson, D.K. (登録日: 2017-10-04, 公開日: 2018-04-25, 最終更新日: 2020-07-29)

• 主引用文献: Monn, J.A.,Henry, S.S.,Massey, S.M.,Clawson, D.K.,Chen, Q.,Diseroad, B.A.,Bhardwaj, R.M.,Atwell, S.,Lu, F.,Wang, J.,Russell, M.,Heinz, B.A.,Wang, X.S.,Carter, J.H.,Getman, B.G.,Adragni, K.,Broad, L.M.,Sanger, H.E.,Ursu, D.,Catlow, J.T.,Swanson, S.,Johnson, B.G.,Shaw, D.B.,McKinzie, D.L.,Hao, J.; Synthesis and Pharmacological Characterization of C4beta-Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1 S,2 S,4 S,5 R,6 S)-2-Amino-4-[(3-methoxybenzoyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193), a Highly Potent and Selective mGlu3Receptor Agonist.; J. Med. Chem., 61:2303-2328, 2018; PubMed: 29350927; DOI: 10.1021/acs.jmedchem.7b01481

実験手法

X-RAY DIFFRACTION (2.82 Å)