6B75
Crystal Structure of human NAMPT in complex with NVP-LOQ594
Summary for 6B75
Entry DOI | 10.2210/pdb6b75/pdb |
Related | 6atb 6AZJ |
Descriptor | Nicotinamide phosphoribosyltransferase, 4-[(piperazin-1-yl)methyl]-N-{[4-({[(pyridin-3-yl)methyl]carbamoyl}amino)phenyl]methyl}benzamide (3 entities in total) |
Functional Keywords | transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 229145.17 |
Authors | Weihofen, W.A.,Thigale, S. (deposition date: 2017-10-03, release date: 2018-10-03, Last modification date: 2023-10-04) |
Primary citation | Palacios, D.,Meredith, E.,Kawanami, T.,Adams, C.,Chen, X.,Darsigny, V.,Geno, E.,Palermo, M.,Guy, C.,Hewett, J.,Tierney, L.,THigale, S.,Weihofen, W.A.,Agrikar, U.,Boynton, G.,George, E.,Wang, L. Identification and structure based design of cellularly active cyclo-propyl carboxamide Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.53 Å) |
Structure validation
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