6B75

Crystal Structure of human NAMPT in complex with NVP-LOQ594

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Nicotinamide phosphoribosyltransferase	polymer	501	56942.4	4	UniProt (P43490) Pfam (PF18127) Pfam (PF04095) In PDB	Homo sapiens (Human)	Nampt,Pre-B-cell colony-enhancing factor 1,Pre-B cell-enhancing factor,Visfatin
2	A, B, D	4-[(piperazin-1-yl)methyl]-N-{[4-({[(pyridin-3-yl)methyl]carbamoyl}amino)phenyl]methyl}benzamide	non-polymer		458.6	3	Chemie (CVP)
3		water	water		18.0	685	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 491 (UniProt: P43490)

PDB	External Database	Details
Leu 492	-	expression tag
Glu 493	-	expression tag
His 494	-	expression tag
His 495	-	expression tag
His 496	-	expression tag
His 497	-	expression tag
His 498	-	expression tag
His 499	-	expression tag
His 500	-	expression tag
His 501	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	227769.5
Non-Polymers*	Number of molecules	3
	Total formula weight	1375.7
All*	Total formula weight	229145.2

*Water molecules are not included.