6B5A

Carbonic anhydrase IX-mimic in complex with nitrogenous base-bearing benezenesulfonamide

Summary for 6B5A

• Entry DOI: 10.2210/pdb6b5a/pdb
• Descriptor: Carbonic anhydrase 2, ZINC ION, 2-(6-amino-9H-purin-9-yl)-N-[2-(4-sulfamoylphenyl)ethyl]acetamide, ... (4 entities in total)
• Functional Keywords: carbonic anhydrase, inhibitor, benzenesulfonamide, purine, adenine, lyase, lyase-inhibitor complex, lyase/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 29285.28

Authors

Lomelino, C.L.,McKenna, R.M. (deposition date: 2017-09-28, release date: 2018-09-05, Last modification date: 2023-10-04)

• Primary citation: Nocentini, A.,Bua, S.,Lomelino, C.L.,McKenna, R.,Menicatti, M.,Bartolucci, G.,Tenci, B.,Di Cesare Mannelli, L.,Ghelardini, C.,Gratteri, P.,Supuran, C.T.; Discovery of New Sulfonamide Carbonic Anhydrase IX Inhibitors Incorporating Nitrogenous Bases.; ACS Med Chem Lett, 8:1314-1319, 2017; PubMed: 29259754; DOI: 10.1021/acsmedchemlett.7b00399

Experimental method

X-RAY DIFFRACTION (1.622 Å)