6B50

Schistosoma mansoni (Blood Fluke) Sulfotransferase/Oxamniquine Complex, T157S Mutant

Summary for 6B50

DescriptorSulfotransferase oxamniquine resistance protein, ADENOSINE-3'-5'-DIPHOSPHATE, {(2S)-7-nitro-2-[(propan-2-ylamino)methyl]-1,2,3,4-tetrahydroquinolin-6-yl}methanol, ... (4 entities in total)
Functional Keywordssulfotransferase, parasite, drug resistance, transferase
Biological sourceSchistosoma mansoni (Blood fluke)
Total number of polymer chains1
Total molecular weight30632.79
Authors
Taylor, A.B. (deposition date: 2017-09-27, release date: 2018-10-10)
Primary citation
LoVerde, P.T.
Why does oxamniquine kill Schistosoma mansoni and not S. haematobium and S. japonicum?
To Be Published,
Experimental method
X-RAY DIFFRACTION (1.87 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.233400 2.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6b50
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Molmil generated image of 6b50
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Molmil generated image of 6b50
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 6b50
no rotation
Molmil generated image of 6b50
rotated about x axis by 90°
Molmil generated image of 6b50
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (6b50.pdb1.gz [46.77 KB])
Coordinate files for Biological unit (6b50.pdb2.gz [91.76 KB])
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