6B3S

Crystal structure of the Fab fragment of necitumumab (Fab11F8) in complex with domain III from a cetuximab resistant variant of EGFR (sEGFRd3-S468R)

6B3S の概要

• エントリーDOI: 10.2210/pdb6b3s/pdb
• 分子名称: Epidermal growth factor receptor, Necitumumab Fab Heavy chain, Necitumumab Fab Light chain, ... (8 entities in total)
• 機能のキーワード: therapeutic antibody, cetuximab resistance, somatic mutation, colorectal cancer, transferase, transferase-immune system complex, transferase/immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 287582.73

構造登録者

Ferguson, K.M.,Bagchi, A. (登録日: 2017-09-23, 公開日: 2017-12-06, 最終更新日: 2023-10-04)

• 主引用文献: Bagchi, A.,Haidar, J.N.,Eastman, S.W.,Vieth, M.,Topper, M.,Iacolina, M.D.,Walker, J.M.,Forest, A.,Shen, Y.,Novosiadly, R.D.,Ferguson, K.M.; Molecular Basis for Necitumumab Inhibition of EGFR Variants Associated with Acquired Cetuximab Resistance.; Mol. Cancer Ther., 17:521-531, 2018; PubMed: 29158469; DOI: 10.1158/1535-7163.MCT-17-0575

実験手法

X-RAY DIFFRACTION (2.8 Å)