6B1O
The structure of DPP4 in complex with Vildagliptin Analog
Summary for 6B1O
Entry DOI | 10.2210/pdb6b1o/pdb |
Descriptor | Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | diabetes, dpp4 inhibitors, covalent inhibitors, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 174107.41 |
Authors | Scapin, G. (deposition date: 2017-09-18, release date: 2017-09-27, Last modification date: 2020-07-29) |
Primary citation | Berger, J.P.,SinhaRoy, R.,Pocai, A.,Kelly, T.M.,Scapin, G.,Gao, Y.D.,Pryor, K.A.D.,Wu, J.K.,Eiermann, G.J.,Xu, S.S.,Zhang, X.,Tatosian, D.A.,Weber, A.E.,Thornberry, N.A.,Carr, R.D. A comparative study of the binding properties, dipeptidyl peptidase-4 (DPP-4) inhibitory activity and glucose-lowering efficacy of the DPP-4 inhibitors alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin in mice. Endocrinol Diabetes Metab, 1:e00002-e00002, 2018 Cited by PubMed: 30815539DOI: 10.1002/edm2.2 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.91 Å) |
Structure validation
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