6B1G
Solution structure of TDP-43 N-terminal domain dimer.
Summary for 6B1G
Entry DOI | 10.2210/pdb6b1g/pdb |
NMR Information | BMRB: 30345 |
Descriptor | TAR DNA-binding protein 43, S48E Mutant, TAR DNA-binding protein 43, Y4R Mutant (2 entities in total) |
Functional Keywords | tdp-43, amyotrophic lateral sclerosis, protein aggregation, rna binding protein, protein self-assembly, dimerization, structural protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 18440.65 |
Authors | Naik, M.T.,Wang, A.,Conicella, A.,Fawzi, N.L. (deposition date: 2017-09-18, release date: 2018-02-28, Last modification date: 2024-05-01) |
Primary citation | Wang, A.,Conicella, A.E.,Schmidt, H.B.,Martin, E.W.,Rhoads, S.N.,Reeb, A.N.,Nourse, A.,Ramirez Montero, D.,Ryan, V.H.,Rohatgi, R.,Shewmaker, F.,Naik, M.T.,Mittag, T.,Ayala, Y.M.,Fawzi, N.L. A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing. EMBO J., 37:-, 2018 Cited by PubMed: 29438978DOI: 10.15252/embj.201797452 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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