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6B1G

Solution structure of TDP-43 N-terminal domain dimer.

Summary for 6B1G
Entry DOI10.2210/pdb6b1g/pdb
NMR InformationBMRB: 30345
DescriptorTAR DNA-binding protein 43, S48E Mutant, TAR DNA-binding protein 43, Y4R Mutant (2 entities in total)
Functional Keywordstdp-43, amyotrophic lateral sclerosis, protein aggregation, rna binding protein, protein self-assembly, dimerization, structural protein
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains2
Total formula weight18440.65
Authors
Naik, M.T.,Wang, A.,Conicella, A.,Fawzi, N.L. (deposition date: 2017-09-18, release date: 2018-02-28, Last modification date: 2020-01-01)
Primary citationWang, A.,Conicella, A.E.,Schmidt, H.B.,Martin, E.W.,Rhoads, S.N.,Reeb, A.N.,Nourse, A.,Ramirez Montero, D.,Ryan, V.H.,Rohatgi, R.,Shewmaker, F.,Naik, M.T.,Mittag, T.,Ayala, Y.M.,Fawzi, N.L.
A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing.
EMBO J., 37:-, 2018
Cited by
PubMed: 29438978
DOI: 10.15252/embj.201797452
PDB entries with the same primary citation
Experimental method
SOLUTION NMR
Structure validation

217705

건을2024-03-27부터공개중

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