6B16

P21-activated kinase 1 in complex with a 4-azaindole inhibitor

Summary for 6B16

Entry DOI	10.2210/pdb6b16/pdb
Descriptor	Serine/threonine-protein kinase PAK 1, N~4~-(5-cyclopropyl-1H-pyrazol-3-yl)-N~2~-[(1S)-1-(1H-pyrrolo[3,2-b]pyridin-5-yl)ethyl]pyrimidine-2,4-diamine, SULFATE ION, ... (4 entities in total)
Functional Keywords	kinase, inhibitor, complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : Q13153
Total number of polymer chains	2
Total formula weight	67963.99
Authors	Rouge, L.,Wang, W. (deposition date: 2017-09-16, release date: 2017-10-25)
Primary citation	Lee, W.,Crawford, J.J.,Aliagas, I.,Murray, L.J.,Tay, S.,Wang, W.,Heise, C.E.,Hoeflich, K.P.,La, H.,Mathieu, S.,Mintzer, R.,Ramaswamy, S.,Rouge, L.,Rudolph, J. Synthesis and evaluation of a series of 4-azaindole-containing p21-activated kinase-1 inhibitors. Bioorg. Med. Chem. Lett., 26:3518-3524, 2016 Cited by PubMed: 27346791 DOI: 10.1016/j.bmcl.2016.06.031 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.285 Å)

Structure validation