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6B0O

Zinc finger Domain of WT1(-KTS form) with 12+1mer Oligonucleotide with 3' Triplet TGT

Summary for 6B0O
Entry DOI10.2210/pdb6b0o/pdb
Related6B0P 6B0Q 6B0R
DescriptorWilms tumor protein, DNA (5'-D(*AP*GP*CP*GP*TP*GP*GP*GP*AP*GP*TP*GP*T)-3'), DNA (5'-D(*TP*AP*CP*AP*CP*TP*CP*CP*CP*AP*CP*GP*C)-3'), ... (6 entities in total)
Functional Keywordsprotein-dna complex wilms tumor suppressor protein zinc-fingers, transcription-dna complex, transcription/dna
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains6
Total formula weight45789.62
Authors
Horton, J.R.,Cheng, X. (deposition date: 2017-09-14, release date: 2018-01-03, Last modification date: 2023-10-04)
Primary citationWang, D.,Horton, J.R.,Zheng, Y.,Blumenthal, R.M.,Zhang, X.,Cheng, X.
Role for first zinc finger of WT1 in DNA sequence specificity: Denys-Drash syndrome-associated WT1 mutant in ZF1 enhances affinity for a subset of WT1 binding sites.
Nucleic Acids Res., 46:3864-3877, 2018
Cited by
PubMed: 29294058
DOI: 10.1093/nar/gkx1274
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.552 Å)
Structure validation

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