6B0N
Crystal structure of the cleavage-independent prefusion HIV Env glycoprotein trimer of the clade A BG505 isolate (NFL construct) in complex with Fabs PGT122 and PGV19 at 3.39 A
Summary for 6B0N
Entry DOI | 10.2210/pdb6b0n/pdb |
Related | 6AVN |
Descriptor | PGV19 Fab heavy chain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (17 entities in total) |
Functional Keywords | viral protein, hiv, envelope, glycoprotein, prefusion trimer, glycan, hiv-1 gp120, hiv-1 gp41, flexible linker, cd4 binding site, vrc01-class lambda antibody, n332 supersite, immune system, neutralizing antibodies, complex, viral protein-immune system complex, viral protein/immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 5 |
Total formula weight | 180256.35 |
Authors | Sarkar, A.,Irimia, A.,Wilson, I.A. (deposition date: 2017-09-14, release date: 2018-05-30, Last modification date: 2023-10-04) |
Primary citation | Sarkar, A.,Bale, S.,Behrens, A.J.,Kumar, S.,Sharma, S.K.,de Val, N.,Pallesen, J.,Irimia, A.,Diwanji, D.C.,Stanfield, R.L.,Ward, A.B.,Crispin, M.,Wyatt, R.T.,Wilson, I.A. Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer. Nat Commun, 9:1956-1956, 2018 Cited by PubMed: 29769533DOI: 10.1038/s41467-018-04272-y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.4 Å) |
Structure validation
Download full validation report