6B09

Crystal structure of HsNUDT16 in complex with diADPR (soaked)

Summary for 6B09

• Entry DOI: 10.2210/pdb6b09/pdb
• Related: 5VY2 5W6X 5W6Z 5WJI
• Descriptor: U8 snoRNA-decapping enzyme, [(2~{R},3~{S},4~{S},5~{S})-5-(6-aminopurin-9-yl)-4-[(2~{S},3~{S},4~{S},5~{S})-5-[[[[(2~{R},3~{R},4~{S},5~{S})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-3,4-bis(oxidanyl)oxolan-2-yl]oxy-3-oxidanyl-oxolan-2-yl]methyl phosphono hydrogen phosphate, MAGNESIUM ION, ... (6 entities in total)
• Functional Keywords: nudix hydrolase, decapping enzyme, demodification of parylation, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 44776.51

Authors

Thirawatananond, P.,Gabelli, S.B. (deposition date: 2017-09-14, release date: 2019-01-09, Last modification date: 2024-03-13)

• Primary citation: Thirawatananond, P.,McPherson, R.L.,Malhi, J.,Nathan, S.,Lambrecht, M.J.,Brichacek, M.,Hergenrother, P.J.,Leung, A.K.L.,Gabelli, S.B.; Structural analyses of NudT16-ADP-ribose complexes direct rational design of mutants with improved processing of poly(ADP-ribosyl)ated proteins.; Sci Rep, 9:5940-5940, 2019; PubMed: 30976021; DOI: 10.1038/s41598-019-39491-w

Experimental method

X-RAY DIFFRACTION (3.2 Å)