6B09

Crystal structure of HsNUDT16 in complex with diADPR (soaked)

6B09 の概要

関連するPDBエントリー5WJI 5W6Z 5W6X 5VY2
分子名称U8 snoRNA-decapping enzyme, [(2~{R},3~{S},4~{S},5~{S})-5-(6-aminopurin-9-yl)-4-[(2~{S},3~{S},4~{S},5~{S})-5-[[[[(2~{R},3~{R},4~{S},5~{S})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-3,4-bis(oxidanyl)oxolan-2-yl]oxy-3-oxidanyl-oxolan-2-yl]methyl phosphono hydrogen phosphate, MAGNESIUM ION, ... (6 entities in total)
機能のキーワードnudix hydrolase, decapping enzyme, demodification of parylation, hydrolase
由来する生物種Homo sapiens (Human)
ポリマー鎖数2
分子量合計44776.51
構造登録者
Thirawatananond, P.,Gabelli, S.B. (登録日: 2017-09-14, 公開日: 2019-01-09, 最終更新日: 2019-04-24)
主引用文献
Thirawatananond, P.,McPherson, R.L.,Malhi, J.,Nathan, S.,Lambrecht, M.J.,Brichacek, M.,Hergenrother, P.J.,Leung, A.K.L.,Gabelli, S.B.
Structural analyses of NudT16-ADP-ribose complexes direct rational design of mutants with improved processing of poly(ADP-ribosyl)ated proteins.
Sci Rep, 9:5940-5940, 2019
PubMed: 30976021 (主引用文献が同じPDBエントリー)
DOI: 10.1038/s41598-019-39491-w
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (3.2 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2779 2.9% 5.1% 4.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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