6B04
Crystal structure of CfFPPS2, a lepidopteran type-II farnesyl diphosphate synthase, complexed with [2-(1-methylpyridin-2-yl)-1-phosphono-ethyl]phosphonic acid (inhibitor 1b)
Summary for 6B04
| Entry DOI | 10.2210/pdb6b04/pdb |
| Related | 6B02 6B06 6B07 |
| Descriptor | Farnesyl diphosphate synthase, 2-(2,2-diphosphonoethyl)-1-methylpyridin-1-ium, MAGNESIUM ION, ... (5 entities in total) |
| Functional Keywords | juvenile hormone, farnesyl diphosphate synthase, inhibitor design, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Choristoneura fumiferana (Spruce budworm moth) |
| Total number of polymer chains | 3 |
| Total formula weight | 118858.68 |
| Authors | Picard, M.-E.,Cusson, M.,Shi, R. (deposition date: 2017-09-13, release date: 2017-12-13, Last modification date: 2024-05-01) |
| Primary citation | Picard, M.E.,Nisole, A.,Beliveau, C.,Sen, S.,Barbar, A.,Shi, R.,Cusson, M. Structural characterization of a lepidopteran type-II farnesyl diphosphate synthase from the spruce budworm, Choristoneura fumiferana: Implications for inhibitor design. Insect Biochem. Mol. Biol., 92:84-92, 2017 Cited by PubMed: 29183817DOI: 10.1016/j.ibmb.2017.11.011 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.83 Å) |
Structure validation
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