6B04
Crystal structure of CfFPPS2, a lepidopteran type-II farnesyl diphosphate synthase, complexed with [2-(1-methylpyridin-2-yl)-1-phosphono-ethyl]phosphonic acid (inhibitor 1b)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004659 | molecular_function | prenyltransferase activity |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| B | 0004659 | molecular_function | prenyltransferase activity |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| C | 0004659 | molecular_function | prenyltransferase activity |
| C | 0008299 | biological_process | isoprenoid biosynthetic process |
| C | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | binding site for residue C6J A 401 |
| Chain | Residue |
| A | ASP147 |
| A | LYS301 |
| A | MG402 |
| A | MG403 |
| A | MG404 |
| A | HOH546 |
| A | HOH548 |
| A | HOH549 |
| A | HOH565 |
| A | HOH570 |
| A | HOH596 |
| A | ASP151 |
| A | HOH642 |
| A | HOH699 |
| A | HOH715 |
| A | ARG156 |
| A | GLN215 |
| A | LYS244 |
| A | THR245 |
| A | TYR248 |
| A | GLN284 |
| A | ASP287 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue MG A 402 |
| Chain | Residue |
| A | ASP147 |
| A | ASP151 |
| A | C6J401 |
| A | MG403 |
| A | HOH533 |
| A | HOH549 |
| A | HOH715 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 403 |
| Chain | Residue |
| A | ASP147 |
| A | ASP151 |
| A | C6J401 |
| A | MG402 |
| A | HOH546 |
| A | HOH699 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 404 |
| Chain | Residue |
| A | ASP287 |
| A | C6J401 |
| A | HOH565 |
| A | HOH570 |
| A | HOH642 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 405 |
| Chain | Residue |
| A | GLU84 |
| A | HOH543 |
| B | ARG236 |
| B | HOH667 |
| site_id | AC6 |
| Number of Residues | 24 |
| Details | binding site for residue C6J B 401 |
| Chain | Residue |
| B | ASP147 |
| B | ASP151 |
| B | ARG156 |
| B | GLN215 |
| B | LYS244 |
| B | THR245 |
| B | TYR248 |
| B | GLN284 |
| B | ASP287 |
| B | LYS301 |
| B | MG402 |
| B | MG403 |
| B | MG404 |
| B | HOH522 |
| B | HOH525 |
| B | HOH542 |
| B | HOH545 |
| B | HOH584 |
| B | HOH594 |
| B | HOH612 |
| B | HOH644 |
| B | HOH647 |
| B | HOH670 |
| B | HOH680 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue MG B 402 |
| Chain | Residue |
| B | ASP147 |
| B | ASP151 |
| B | C6J401 |
| B | MG403 |
| B | HOH525 |
| B | HOH546 |
| B | HOH680 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 403 |
| Chain | Residue |
| B | ASP147 |
| B | ASP151 |
| B | C6J401 |
| B | MG402 |
| B | HOH522 |
| B | HOH647 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 404 |
| Chain | Residue |
| B | ASP287 |
| B | C6J401 |
| B | HOH545 |
| B | HOH594 |
| B | HOH644 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 405 |
| Chain | Residue |
| B | PRO377 |
| B | SER378 |
| B | GLU379 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 406 |
| Chain | Residue |
| A | LEU217 |
| A | HOH725 |
| B | GLU84 |
| B | HOH650 |
| site_id | AD3 |
| Number of Residues | 24 |
| Details | binding site for residue C6J C 401 |
| Chain | Residue |
| C | TYR248 |
| C | GLN284 |
| C | ASP287 |
| C | LYS301 |
| C | MG402 |
| C | MG403 |
| C | MG404 |
| C | HOH527 |
| C | HOH528 |
| C | HOH540 |
| C | HOH548 |
| C | HOH559 |
| C | HOH574 |
| C | HOH635 |
| C | HOH649 |
| C | HOH658 |
| C | HOH679 |
| C | HOH696 |
| C | ASP147 |
| C | ASP151 |
| C | ARG156 |
| C | GLN215 |
| C | LYS244 |
| C | THR245 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue MG C 402 |
| Chain | Residue |
| C | ASP147 |
| C | ASP151 |
| C | C6J401 |
| C | MG403 |
| C | HOH528 |
| C | HOH547 |
| C | HOH696 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue MG C 403 |
| Chain | Residue |
| C | ASP147 |
| C | ASP151 |
| C | C6J401 |
| C | MG402 |
| C | HOH527 |
| C | HOH649 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue MG C 404 |
| Chain | Residue |
| C | ASP287 |
| C | C6J401 |
| C | HOH540 |
| C | HOH574 |
| C | HOH635 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue EDO C 405 |
| Chain | Residue |
| C | ASN96 |
| C | ASP148 |
| C | CYS161 |
| C | TRP162 |
| C | HOH545 |
| C | HOH581 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO C 406 |
| Chain | Residue |
| C | GLU84 |
| C | HOH660 |
| C | HOH678 |
Functional Information from PROSITE/UniProt
